File:Regulation of the core and extended pluripotency networks in mouse embryonic stem cells.png

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Description Figure 6. Regulation of the core and extended pluripotency networks in mouse embryonic stem cells. Maintenance of pluripotency and self-renewal is governed by external stimuli (red), which act on various signalling pathways (green) that regulate the expression of the extended (blue) and core (purple) pluripotency networks. In turn, the expression of transcription factors of the core circuitry regulates their own expression, as well as the expression of other factors involved in differentiation and/or self-renewal (orange). Figure adapted from data published in: (Jirmanova et al., 2002; Mitsui et al., 2003; Ying et al., 2003a; Paling et al., 2004; Hamazaki et al., 2006; Binétruy et al., 2007; Kunath et al., 2007; Storm et al., 2007, 2009; Chen et al., 2008; Medvedev et al., 2008; Niwa et al., 2009; Hall et al., 2009b; Hirai et al., 2011; Wray et al., 2011; Kim et al., 2012; Marks et al., 2012; Nichols and Smith, 2012; Romero-Lanman et al., 2012; Do et al., 2013; Lee, 2013; Hamilton and Brickman, 2014; Posfai et al., 2014; Tosolini and Jouneau, 2015).
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Source https://www.researchgate.net/figure/Regulation-of-the-core-and-extended-pluripotency-networks-in-mouse-embryonic-stem_fig5_334407321 https://www.researchgate.net/publication/334407321_Modeling_Mammalian_Commitment_to_the_Neural_Lineage_Using_Embryos_and_Embryonic_Stem_Cells Modeling Mammalian Commitment to the Neural Lineage Using Embryos and Embryonic Stem Cells. July 2019. Frontiers in Physiology 10 DOI:10.3389/fphys.2019.00705
Author Rachel A. Shparberg, Hannah J. Glover, Michael B. Morris
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Copyright © 2019 Shparberg, Glover and Morris. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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current00:24, 30 April 2024Thumbnail for version as of 00:24, 30 April 20241,217 × 1,171 (780 KB)Rasbak (talk | contribs){{Information |description=Figure 6. Regulation of the core and extended pluripotency networks in mouse embryonic stem cells. Maintenance of pluripotency and self-renewal is governed by external stimuli (red), which act on various signalling pathways (green) that regulate the expression of the extended (blue) and core (purple) pluripotency networks. In turn, the expression of transcription factors of the core circuitry regulates their own expression, as well as the expression of other factors...

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