File:Schematic of RNA timestamp workflow, 4 steps.png
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DescriptionSchematic of RNA timestamp workflow, 4 steps.png |
English: The first step is for the RNA of interest to be tagged with the timestamp. Next, as the time stamp is transcribed, the adenosine rich repeat regions (editing array) slowly are converted to inosines by ADARcd2 (depicted as ADAR). ADAR is bound to the MS2 binding sites of the timestamp. The accumulation of A-to-I edits can be read through sequencing technologies such as RNA-seq. (This image is an original work with some elements having been adapted from the work of Rodriques, S.G., Chen, L.M., Liu, S. et al. RNA timestamps identify the age of single molecules in RNA sequencing. Nat Biotechnol 39, 320–325 (2021). https://doi.org/10.1038/s41587-020-0704-z) |
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Author | Elizabethstephens21 |
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current | 16:25, 24 March 2021 | 1,190 × 481 (112 KB) | Elizabethstephens21 (talk | contribs) | Uploaded own work with UploadWizard |
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