File:TETs showed a catalytic region in their C-terminal, with methylcytosine dioxygenase activity.jpg
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| Description | Figure 1. TETs showed a catalytic region in their C-terminal, with methylcytosine dioxygenase activity, composed by a conserved domain rich in cysteine (Cys-rich); and a double-stranded β-helix domain (DSHB), which interacts with 2OG and Fe (II). At the N-terminal region, TET1 and TET3 show a CXXC domain, which binds to unmodied cytosine; Conversely, as a consequence of a chromosome inversion during evolution, this domain is not present in TET2; the CXXC was separated and gave origin to the IDAX gene, which acts as its negative regulator |
| Date | |
| Source | https://www.researchgate.net/publication/337074348_TET_enzymes_and_key_signalling_pathways_Crosstalk_in_embryonic_development_and_cancer TET enzymes and key signalling pathways: Crosstalk in embryonic development and cancer. Integr Cancer Sci Therap 6: DOI: 10.15761/ICST.1000318. |
| Author | Tone Salomão KB, Veiga Cruzeiro GA, Ferreira das Chagas P, Bonfim-Silva R, Brassesco M, et al. |
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Copyright: ©2019 Salomão KB. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
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| current | 14:55, 22 May 2024 | | 1,258 × 587 (261 KB) | Rasbak (talk | contribs) | {{Information |description= Figure 1. TETs showed a catalytic region in their C-terminal, with methylcytosine dioxygenase activity, composed by a conserved domain rich in cysteine (Cys-rich); and a double-stranded β-helix domain (DSHB), which interacts with 2OG and Fe (II). At the N-terminal region, TET1 and TET3 show a CXXC domain, which binds to unmodied cytosine; Conversely, as a consequence of a chromosome inversion during evolution, this domain is not present in TET2; the CX... |
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