File:TGF-β signaling is regulated by primary cilia.png
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| Description | Figure 3. TGF-β signaling is regulated by primary cilia. In the presence of primary cilia, p-TGF-β-RI, p-SMAD2, and SMAD4 are localized on the cilia, while p-SMAD3 is localized on the ciliary base. Stimulation of the receptor with TGF-β ligand results in increased nuclear localization of active SMAD2/3/4 complex. In the absence of cilia, while p-SMAD3 is still localized on the ciliary base, its nuclear localization is diminished as well as the abundance of SMAD2/3 complex in the cell. Created with BioRender.com. |
| Date | |
| Source | https://doi.org/10.3390/cells10061428 Cilium Is Involved in Stem Cell Differentiation and Renewal through the Regulation of Multiple Signaling Pathways. Cells 2021, 10, 1428. |
| Author | Yanardag, S.; Pugacheva, E.N. Primary |
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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 10:24, 5 May 2024 | | 3,044 × 2,598 (1.96 MB) | Rasbak (talk | contribs) | {{Information |description=Figure 3. TGF-β signaling is regulated by primary cilia. In the presence of primary cilia, p-TGF-β-RI, p-SMAD2, and SMAD4 are localized on the cilia, while p-SMAD3 is localized on the ciliary base. Stimulation of the receptor with TGF-β ligand results in increased nuclear localization of active SMAD2/3/4 complex. In the absence of cilia, while p-SMAD3 is still localized on the ciliary base, its nuclear localization is diminished as well as the abundance of SMAD2/3 c... |
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