File:TRIM regulation of PRR pathways.jpg
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English: TRIMs are involved in the regulation of the stability and activity of PRR components in all cascades of the signaling pathways, including ligands, receptors, adaptors, TRAFs, kinases and associated regulators, and the final transcription factors (TFs). An increasing pool of regulatory factors of the PRR pathways is also regulated by TRIMs (not shown). TRIMs promoting the stability or activity of the targets are shown on the left of the targets (blue), and those inhibiting the targets are shown on the right of the targets (brown). TRIM19IV and TRIM21 positively regulate phosphorylated IRF3 in indirect manners via Pin1. As such, TRIM8 positively regulates phosphorylated IRF7 in an indirect manner via Pin1. Other indirect regulation of these PRR pathways by TRIMs are not shown. |
| Date | |
| Source | Own work |
| Author | Sbning |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 16:05, 17 February 2023 | | 2,339 × 1,654 (830 KB) | Sbning (talk | contribs) | Uploaded while editing "Tripartite motif family" on en.wikipedia.org |
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