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English: The production of cellular therapies requires the optimization of four steps: first, isolating and culturing cells that can be readily obtained from a patient in a non-invasive fashion. Second, the reprogramming of these cells into a pluripotent state. Third, the directed differentiation of those patient-specific pluripotent cells into the cell type relevant to their disease. And, fourth, techniques for repairing any intrinsic disease-causing genetic defects and transplantation of the repaired, differentiated cells into the patient. Notably, these disease-relevant patient cells can also be used for in vitro disease modeling which may yield new insights into disease mechanisms and drug discovery. |
日期 | Published September 30, 2008. |
来源 |
[1] Direct
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作者 | Rodolfa, K.T., Inducing pluripotency (September 30, 2008), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.22.1, http://www.stembook.org. |
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当前 | 2013年4月5日 (五) 18:57 | 432 × 430(55 KB) | Smallbot(留言 | 贡献) | Uploading CC-BY images from the the StemBook http://www.stembook.org/ 114/173 |
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