File:TopBP1 oligomerization and transcriptional regulation.png

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TopBP1 mediated transcriptional regulation of E2F-1 target genes.

Summary[edit]

Description
English: Following DNA damage, TopBP1 is phosphorylated by Akt and self oligomerizes at the BRCT7/8 domains. Oligomeric TopBP1 can bind to E2F-1 and recruit chromatin remodeling machinery (e.g. HDAC) to repress E2F-1 driven gene expression.
Date
Source Own work
Author Cpt01

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Date/TimeThumbnailDimensionsUserComment
current22:43, 28 November 2022Thumbnail for version as of 22:43, 28 November 20222,207 × 905 (253 KB)Cpt01 (talk | contribs)reformatted shapes
22:45, 27 November 2022Thumbnail for version as of 22:45, 27 November 20222,207 × 905 (79 KB)Cpt01 (talk | contribs)Uploaded own work with UploadWizard

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