File:Hcmvdrugs.pdf
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[edit]DescriptionHcmvdrugs.pdf |
English: Mechanisms of anti-HCMV compounds. Ganciclovir (GCV) is monophosphorylated by the HCMV protein kinase pUL97. Cidofovir (CDV) does not require initial phosphorylation for its antiviral action. Further phosphorylation to the triphosphate form of GCV and CDV is performed by cellular kinases. The nucleoside-triphosphate-analogues compete with the cellular nucleotide triphosphates at the viral polymerase pUL54 and are incorporated into the viral DNA. Foscarnet (FOS) directly inhibits polymerase function by blocking the pyrophosphate binding site. |
Date | |
Source | Own work |
Author | Nepomuk78 |
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Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.2 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the section entitled GNU Free Documentation License.http://www.gnu.org/copyleft/fdl.htmlGFDLGNU Free Documentation Licensetruetrue |
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 17:28, 13 April 2011 | 1,641 × 1,125 (90 KB) | Nepomuk78 (talk | contribs) | {{Information |Description ={{en|1=Mode of action of systemic HCMV drugs}} |Source ={{own}} |Author =Nepomuk78 |Date =2011-04-13 |Permission = |other_versions = }} |
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Short title | hcmvdrugs.graffle |
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Author | Johann Kraus |
Software used | OmniGraffle Professional 5.1.1 |
Conversion program | Mac OS X 10.6.7 Quartz PDFContext |
Encrypted | no |
Version of PDF format | 1.3 |
Page size | 788 x 540 pts |