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English: In linguistics, the term “metabolomics” originates from the Greek words “metabole” and “nomos.” The first mention of the two signifies “alter or change,” while the latter signifies “rule or law.” As one of the latest “omics” sciences following genomics, transcriptomics, and proteomics, metabolomics is a vital component of system biology, which aims to offer a countermeasure for integrated analysis and assessment of low-molecular-weight compounds in their intricate biological context. Generally speaking, the metabolomic protocol comprises collecting samples, preparing samples, acquiring data, and analyzing data. Every stage encompasses various steps and critical points, and some great reviews are available for the details. As the end products of the diverse alteration that happens in the genome, transcriptome, and proteome, metabolites can closely stand for the phenotypic fingerprints of an organic system (cell, tissue, etc.). Collectively, the goals of metabolomics are to obtain a good understanding of the physiological and pathological state and to aid the development of modified therapeutic agents in managing disease situations.