File talk:GPCR-Zyklus.png

The picture is wrong in one way: in not showing the correct attachment of G-protein monomers to the membrane. Correct would be attaching alpha and gamma subunits, but not beta, which binds to the membrane via gamma. See this: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC98917/figure/F5/ and/or this: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389521/figure/F6/ "All Gα subunits (except Gαt) are palmitoylated and/or myristoylated at their N-terminus allowing anchor age to the plasma membrane." "Gγ subunits exhibit farnesylation or geranylgeranylation modifications cooperating in trans with Gα acylation to allow proper targeting of Gαβγ trimers from the endoplasmic reticulum to the plasma membrane [18]. As Gβ subunits lack lipid modifications, Gγsubunits act as chaperones for Gβ targeting to the plasma membrane." - citing the second article.