File:ATX-2-the-C.-elegans-Ortholog-of-Human-Ataxin-2-Regulates-Centrosome-Size-and-Microtubule-Dynamics-pgen.1006370.s007.ogv

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Original file ‎(Ogg Theora video file, length 8.0 s, 834 × 294 pixels, 431 kbps, file size: 421 KB)

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English: ATX-2 is required for proper cell division. Embryos expressing GFP-α-Tubulin, mCherry-γ-Tubulin and mCherry-H2B. The atx-2(RNAi) embryo contains extra DNA, presumably resulting from polar body extrusion failure during meiosis (see S3 Movie). Before pronuclei meet, the spindle starts to form only around the sperm pronucleus, followed by later incorporation of the maternal DNA into the spindle. The atx-2(RNAi) embryo displays abnormal spindle positioning, improperly positioned axis of the metaphase plate, and lagging DNA at first anaphase. The atx-2(RNAi) embryo duplicates centrosomes properly but fails to complete cytokinesis (see S2 Movie), forming a tetrapolar spindle at the second mitosis. Note that in the atx-2(RNAi) embryo, centrosomes labeled with mCherry-γ-Tubulin is significantly larger than in the control. Also note shorter metaphase spindle and cell cycle delay in atx-2(RNAi) embryo compared to the control. Each frame is equal to 1 min of elapsed time (t = 0 at first metaphase; 5 fps). Bar, 5 μm.
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Source S1 Movie from Stubenvoll M, Medley J, Irwin M, Song M (2016). "ATX-2, the C. elegans Ortholog of Human Ataxin-2, Regulates Centrosome Size and Microtubule Dynamics". PLOS Genetics. DOI:10.1371/journal.pgen.1006370. PMID 27689799. PMC: 5045193.
Author Stubenvoll M, Medley J, Irwin M, Song M
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Date/TimeThumbnailDimensionsUserComment
current05:40, 29 October 20168.0 s, 834 × 294 (421 KB)Open Access Media Importer Bot (talk | contribs)Automatically uploaded media file from Open Access source. Please report problems or suggestions here.

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Format Bitrate Download Status Encode time
VP9 360P 81 kbps Completed 04:51, 16 August 2018 3.0 s
Streaming 360p (VP9) 81 kbps Completed 21:42, 17 December 2023 1.0 s
VP9 240P 43 kbps Completed 04:50, 16 August 2018 2.0 s
Streaming 240p (VP9) 43 kbps Completed 09:27, 9 December 2023 1.0 s
WebM 360P 464 kbps Completed 05:40, 29 October 2016 2.0 s
Streaming 144p (MJPEG) 155 kbps Completed 13:36, 29 October 2023 1.0 s

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