File:Aves A model based on local cell behaviours explains the global movements in the epiblast and experimental conditions.jpg

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Fig 7. A model based on local cell behaviours explains the global movements in the epiblast and experimental conditions.

(A–E) Epithelial intercalation in a posterior domain (orange) and EMT (blue, isolated events, cooperative in the pink domain) are sufficient to explain the formation of the PS. (A–C) sequence in time, vertical view; (D) ventral view of the epiblast; (E) apical view of the epiblast. (F–H) Sequence from a time-lapse experiment, with cells in the intercalation domain electroporated with control morpholino (green) and other locations in the epiblast labelled with DiI (red). (F) initial condition, 6 hr before streak formation; (G) movements prior to streak formation; (H) movements over 6 hr after PS forms. (I and J) Movements observed in the same time-frame as in F–H, when intercalation is blocked by electroporating morpholinos (green) against the Wnt-PCP pathway. (K–O) The computer model correctly simulates the observed movements both in normal embryos (K–M) and in intercalation-compromised condition (N and O). (P–R) Hypoblast rotation at pre-PS stages leads to bending of the PS. (P) Experimental embryo, with the PS marked by Bra expression; the model accounts for this result (red in Q) by the induction of a new intercalation domain (yellow in R) which deforms the original one and the field of cooperative ingression (orange in R). (S and T) EMT cells can trigger a chain reaction of EMT and initiate a new PS in both experimental embryos (S) and in the model (T).
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Source https://elifesciences.org/articles/1817#fig6s1 https://doi.org/10.7554/eLife.01817 Local cell interactions and self-amplifying individual cell ingression drive amniote gastrulation eLife 3:e01817.
Author Octavian Voiculescu Lawrence Bodenstein I-Jun Lau Claudio D Stern
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current21:12, 16 April 2024Thumbnail for version as of 21:12, 16 April 20241,500 × 1,199 (501 KB)Rasbak (talk | contribs){{Information |description=Fig 7. A model based on local cell behaviours explains the global movements in the epiblast and experimental conditions.<br> (A–E) Epithelial intercalation in a posterior domain (orange) and EMT (blue, isolated events, cooperative in the pink domain) are sufficient to explain the formation of the PS. (A–C) sequence in time, vertical view; (D) ventral view of the epiblast; (E) apical view of the epiblast. (F–H) Sequence from a time-lapse experiment, with cells in the...

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