File:Laron syndrome 01.jpg
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DescriptionLaron syndrome 01.jpg |
English: Impact of insulin/IGF-1 signaling in Laron syndrome (A) and Western diet (B) on FoxO-mediated gene regulation and associated pathologies. GHR*, growth hormone receptor loss of function mutation in Laron syndrome; GIP, glucose-dependent insulinotropic polypeptide, a whey protein-induced incretin, which stimulates β-cell proliferation and insulin secretion; PRL, prolactin; PRL secretion is induced by serotoninergic hypothalamic signaling; Trp, tryptophan, and Leu, leucine, essential amino acids enriched in the whey protein α-lactalbumin; Trp via serotonin synthesis stimulates pituitary GH and PRL secretion and Leu stimulates β-cell proliferation and insulin secretion. |
Date | published 24 June 2011 |
Source | B. C. Melnik, S. M. John, G. Schmitz: Over-stimulation of insulin/IGF-1 signaling by western diet may promote diseases of civilization: lessons learnt from laron syndrome. In: Nutrition & metabolism Band 8, 2011, p. 41, ISSN 1743-7075. doi:10.1186/1743-7075-8-41. PMID 21699736. |
Author | B. C. Melnik, S. M. John, G. Schmitz |
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 20:45, 20 July 2011 | 1,109 × 812 (245 KB) | Kuebi (talk | contribs) | {{Information |Description={{en|Impact of insulin/IGF-1 signaling in Laron syndrome (A) and Western diet (B) on FoxO-mediated gene regulation and associated pathologies. GHR*, growth hormone receptor loss of function mutation in Laron syndrome; GIP, gluco |
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Horizontal resolution | 28 dpc |
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Software used | Adobe Photoshop 7.0 |
File change date and time | 22:41, 20 July 2011 |
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