File:Molecular-Dynamics-of-Fuzzy-Transcriptional-Activator-Coactivator-Interactions-pcbi.1004935.s002.ogv

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Original file ‎(Ogg Theora video file, length 33 s, 848 × 1,008 pixels, 6.92 Mbps, file size: 27.52 MB)

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English: Differential occupation of GAL11-ABD1 pockets #1 and #2. The GAL11-ABD1 structure is shown as a surface representation in silver. The GCN4 cAD is drawn as a purple ribbon. The GCN4 key hydrophobic residues are displayed as liquorice models (W120: cyan; F124: neon green). At the start of the movie (seconds 0–8), pocket #1 is exclusively occupied by F124. Later (seconds 9–28), F124 occupies pocket #1 exclusively. Towards the end (seconds 29–32), both W120 and F124 bind to a pocket merged from the originally separate pockets #1 and #2 (see also Fig 1C). The trajectory is from GAL11-ABD1/GCN4-cAD_aMD_no1 and represents one microsecond of accelerated aMD.
Date
Source S1 Movie from Scholes N, Weinzierl R (2016). "Molecular Dynamics of "Fuzzy" Transcriptional Activator-Coactivator Interactions". PLOS Computational Biology. DOI:10.1371/journal.pcbi.1004935. PMID 27175900. PMC: 4866707.
Author Scholes N, Weinzierl R
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This file was transferred to Wikimedia Commons from PubMed Central by way of the Open Access Media Importer.
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current07:04, 18 October 201633 s, 848 × 1,008 (27.52 MB)Open Access Media Importer Bot (talk | contribs)Automatically uploaded media file from Open Access source. Please report problems or suggestions here.

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