File:Predictors-of-Hepatitis-B-Cure-Using-Gene-Therapy-to-Deliver-DNA-Cleavage-Enzymes-A-Mathematical-pcbi.1003131.s001.ogv

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Original file ‎(Ogg Theora video file, length 1 min 4 s, 832 × 672 pixels, 238 kbps, file size: 1.83 MB)

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English: Simulation with weekly dosing of HBV DNA cleavage enzymes. The number of cells with a given combination of susceptible remaining genomes (x-axis) and resistant remaining genomes (y-axis) is displayed following each dose. The goal of an eradicative therapy is for all cells to enter the top left box (no sensitive or resistant viral genomes). This simulation of a potent regimen with high fMOI (m*σ = 5), high enzyme – DNA binding avidity (d = 0.04), and positive binding cooperativity (h = 2), as well as high resistance rate (0.05), leads to >1010 cells harboring 1 or more enzyme sensitive genome, >109 cells harboring one resistant genome only and >108 cells harboring 2 or more resistant genomes only at 140 days (or 20 doses) following initiation of therapy.
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Source Movie S1 from Schiffer J, Swan D, Stone D, Jerome K (2013). "Predictors of Hepatitis B Cure Using Gene Therapy to Deliver DNA Cleavage Enzymes: A Mathematical Modeling Approach". PLOS Computational Biology. DOI:10.1371/journal.pcbi.1003131. PMID 23861664. PMC: 3701691.
Author Schiffer J, Swan D, Stone D, Jerome K
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current12:17, 1 August 20131 min 4 s, 832 × 672 (1.83 MB)Open Access Media Importer Bot (talk | contribs)Automatically uploaded media file from Open Access source. Please report problems or suggestions here.

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