File:Three different types of reporter gene reporter probe strategies..jpg

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English: (A) Enzyme-based bioluminescence imaging. D-Luciferin is a substrate molecular probe that is acted upon by the enzyme Firefly Luciferase to result in bioluminescence via a chemiluminescent reaction under physiological conditions only within living cells expressing the firefly luciferase (fluc) gene. (B) Enzyme-based PET imaging. 18F-Fluoropenciclovir (18F-FPCV) or other acycloguanosines are substrate molecular probes phosphorylated by the herpes simplex virus type 1 thymidine kinase (HSV1-TK) enzyme to result in intracellular trapping of the probe in cells expressing the HSV1-tk gene. C) Receptor-based PET imaging. 18F-FESP is a ligand molecular probe interacting with the dopamine-2-receptor (D2R) to result in trapping of the probe on/in cells expressing the D2R gene. From Wu JC et al. J Nuc Cardiol 2004 Jul-Aug 11(4):491–505 with permission.
Date Published July 30, 2009.
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StemBook Figure 3 Three different types of reporter gene reporter probe strategies.

  • Rodriguez-Porcel, M., Wu, J.C., and Gambhir, S.S., Molecular imaging of stem cells (July 30, 2009), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.49.1, http://www.stembook.org.
Author Rodriguez-Porcel, M., Wu, J.C., and Gambhir, S.S., Molecular imaging of stem cells (July 30, 2009), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.49.1, http://www.stembook.org.
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