File:Transgenic-Drosophila-for-Investigating-DUX4-and-FRG1-Two-Genes-Associated-with-Facioscapulohumeral-pone.0150938.s002.ogv

English: Increased FRG1 expression in adult muscle impairs flight (Part 1). Groups of flies were analyzed for the ability to fly. Flies were forcibly dislodged from the surface of a vial and scored for their ability to prevent themselves from falling to the bottom by flying. Those that fell were scored as unable to fly; those that immediately lit upon the sides of the vials did so via flight, thus preventing themselves from falling, and were scored as capable of flying. The adult muscle GAL4 driver strain DJ667 (left) and the UAS-DmFRG1 strain (right) were readily able to flying upon being dislodged and return to the sides of the vial. However, the DJ667 GAL4, UAS-DmFRG1 progeny (middle), which produced flies overexpressing DmFRG1 in their adult muscles, were unable to fly and fell to the bottom of the vial when dislodged.