File:ADMP establishes a self-regulatory network that controls the size of the organizer domain Spemann's organizer.jpg
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| Description | ADMP establishes a self-regulatory network that controls the size of the organizer domain. Model for the ADMP-mediated self-regulatory control of organizer size. a During the onset of gastrulation ADMP and Alk2 are already robustly expressed within the organizer. This ligand-receptor pair promotes the enlargement of the organizer and expression of the organizer-specific genes. At this stage, the expression of chordin is low. b With the progression of gastrulation, the expression of ADMP continues to increase, thus allowing the diffusion or shuttling of ADMP to lateral regions flanking the organizer. c In the lateral marginal zone (LMZ), the ALK1 receptor is expressed and the ADMP/ALK1 ligand-receptor pair prevents further expansion of the organizer |
| Date | |
| Source | https://doi.org/10.1186/s12915-018-0483-x ADMP controls the size of Spemann's organizer through a network of self-regulating expansion-restriction signals. BMC Biol 16, 13 (2018). |
| Author | Leibovich, A., Kot-Leibovich, H., Ben-Zvi, D. et al. |
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| current | 18:59, 23 April 2024 | | 1,011 × 529 (263 KB) | Rasbak (talk | contribs) | {{Information |description=ADMP establishes a self-regulatory network that controls the size of the organizer domain. Model for the ADMP-mediated self-regulatory control of organizer size. a During the onset of gastrulation ADMP and Alk2 are already robustly expressed within the organizer. This ligand-receptor pair promotes the enlargement of the organizer and expression of the organizer-specific genes. At this stage, the expression of chordin is low. b With the progression of gastrulation, t... |
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