File:Characterization of autonomic symptom burden in long COVID- A global survey of 2,314 adults.pdf
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DescriptionCharacterization of autonomic symptom burden in long COVID- A global survey of 2,314 adults.pdf |
English: Background: Autonomic dysfunction is a known complication of post-acute sequelae of SARS-CoV-2 (PASC)/long COVID, however prevalence and severity are unknown.
Objective: To assess the frequency, severity, and risk factors of autonomic dysfunction in PASC, and to determine whether severity of acute SARS-CoV-2 infection is associated with severity of autonomic dysfunction. Design: Cross-sectional online survey of adults with PASC recruited through long COVID support groups between October 2020 and August 2021. Participants: 2,413 adults ages 18–64 years with PASC including patients who had a confirmed positive test for COVID-19 (test-confirmed) and participants who were diagnosed with COVID-19 based on clinical symptoms alone. Main measures: The main outcome measure was the Composite Autonomic Symptom 31 (COMPASS-31) total score, used to assess global autonomic dysfunction. Test-confirmed hospitalized vs. test-confirmed non-hospitalized participants were compared to determine if the severity of acute SARS-CoV-2 infection was associated with the severity autonomic dysfunction. Key results: Sixty-six percent of PASC patients had a COMPASS-31 score >20, suggestive of moderate to severe autonomic dysfunction. COMPASS-31 scores did not differ between test-confirmed hospitalized and test-confirmed non-hospitalized participants [28.95 (15.62, 46.60) vs. 26.4 (13.75, 42.10); p = 0.06]. Conclusions: Evidence of moderate to severe autonomic dysfunction was seen in 66% of PASC patients in our study, independent of hospitalization status, suggesting that autonomic dysfunction is highly prevalent in the PASC population and independent of the severity of acute COVID-19 illness. |
Date | |
Source | https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.1012668/pdf?isPublishedV2=false |
Author | Nicholas W. Larsen, Lauren E. Stiles, Ruba Shaik, Logan Schneider, Srikanth Muppidi, Cheuk To Tsui, Linda N. Geng, Hector Bonilla, Mitchell G. Miglis |
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Short title | Characterization of autonomic symptom burden in long COVID: A global survey of 2,314 adults |
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Image title | Background: Autonomic dysfunction is a known complication of post-acute sequelae of SARS-CoV-2 (PASC)/long COVID, however prevalence and severity are unknown. |
Author | Mitchell G. Miglis |
Keywords |
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Software used | LaTeX with hyperref package + hypdvips |
Conversion program | dvips + MiKTeX GPL Ghostscript 9.0 |
Encrypted | no |
Page size | 595.26 x 842.116 pts (A4) |
Version of PDF format | 1.4 |