File:Electron-Tomography-of-HIV-1-Infection-in-Gut-Associated-Lymphoid-Tissue-ppat.1003899.s009.ogv
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Electron-Tomography-of-HIV-1-Infection-in-Gut-Associated-Lymphoid-Tissue-ppat.1003899.s009.ogv (Ogg Theora video file, length 2 min 33 s, 768 × 576 pixels, 622 kbps, file size: 11.37 MB)
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[edit]DescriptionElectron-Tomography-of-HIV-1-Infection-in-Gut-Associated-Lymphoid-Tissue-ppat.1003899.s009.ogv |
English: Large-area tomographic reconstruction of an intercellular space near the edge of an HIV-1–infected crypt from BLT mouse colon. The movie begins with a summary of the region defined in the volume: an intercellular space separating two adjacent cells (dark green and brown) near the edge of an HIV-1–infected crypt. HIV-1 buds (blue with magenta cores) were present on both cells, demonstrating that both were infected human cells. The tomographic reconstruction of the same area shown after the summary consisted of four serial 300 nm sections, each imaged as two-frame dual-axis tomograms to encompass a volume of 1.4 µm×2.9 µm×1.2 µm. The intercellular space contained ≥300 free, mature HIV-1 virions and no free immature virions. No structural evidence of direct cell-to-cell viral transmission was present in the volume. This reconstruction supports the assumption that virion pools were not necessarily a consequence of the juxtaposition of human and murine cells within the BLT mouse system. Instead pool formation and infection by free virus may occur even when adjacent cells were HIV-1 targets, further suggesting that maturation of HIV-1 occurs quickly following scission from the host cell. |
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Source | Movie S1 from Ladinsky M, Kieffer C, Olson G, Deruaz M, Vrbanac V, Tager A, Kwon D, Bjorkman P (2014). "Electron Tomography of HIV-1 Infection in Gut-Associated Lymphoid Tissue". PLOS Pathogens. DOI:10.1371/journal.ppat.1003899. PMC: 3907528. | ||
Author | Ladinsky M, Kieffer C, Olson G, Deruaz M, Vrbanac V, Tager A, Kwon D, Bjorkman P | ||
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This file is licensed under the Creative Commons Attribution 4.0 International license.
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 21:37, 5 February 2014 | 2 min 33 s, 768 × 576 (11.37 MB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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This file contains additional information such as Exif metadata which may have been added by the digital camera, scanner, or software program used to create or digitize it. If the file has been modified from its original state, some details such as the timestamp may not fully reflect those of the original file. The timestamp is only as accurate as the clock in the camera, and it may be completely wrong.
Author | Ladinsky M, Kieffer C, Olson G, Deruaz M, Vrbanac V, Tager A, Kwon D, Bjorkman P |
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Usage terms | http://creativecommons.org/licenses/by/4.0/ |
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Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2014-01 |