File:Genetic-and-pharmacological-inhibition-of-calcineurin-corrects-the-BDNF-transport-defect-in-1756-6606-2-33-S1.ogv

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Genetic-and-pharmacological-inhibition-of-calcineurin-corrects-the-BDNF-transport-defect-in-1756-6606-2-33-S1.ogv ‎(Ogg Theora video file, length 4.8 s, 298 × 200 pixels, 568 kbps, file size: 335 KB)

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English: FK506 increases BDNF vesicular transport in rat cortical neurons expressing polyQ-huntingtin. Representative movies showing dynamics of BDNF-mCherry vesicles in neurites

from rat cortical neurons ectopically expressing the first 480 amino acids of huntingtin containing 68Q repeats (480-68Q, mutant). The upper movies shows DMSO treated neurons and the lower movies neurons treated with 1 µM FK506 during 30 min. For each movies, 6 randomly chosen vesicles were tracked and visualized as dots using ImageJ software. Videomicroscopy experiments were done as in Methods except that images were collected during 2 minutes at a frequency of 1 image/s with an acquisition time of 300 ms. Scale bar

corresponds to 5 µm.
Date
Source Pineda J, Pardo R, Zala D, Yu H, Humbert S, Saudou F (2009). "Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's disease". Molecular Brain. DOI:10.1186/1756-6606-2-33. PMID 19860865. PMC: 2776580.
Author Pineda J, Pardo R, Zala D, Yu H, Humbert S, Saudou F
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This file was transferred to Wikimedia Commons from PubMed Central by way of the Open Access Media Importer.
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current00:10, 20 November 20124.8 s, 298 × 200 (335 KB)Open Access Media Importer Bot (talk | contribs)Automatically uploaded media file from Open Access source. Please report problems or suggestions here.

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VP9 240P Not ready Unknown status
Streaming 240p (VP9) 160 kbps Completed 02:11, 22 December 2023 3.0 s
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Streaming 144p (MJPEG) 845 kbps Completed 02:12, 14 November 2023 1.0 s

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