File:Genetic-and-pharmacological-inhibition-of-calcineurin-corrects-the-BDNF-transport-defect-in-1756-6606-2-33-S2.ogv
Genetic-and-pharmacological-inhibition-of-calcineurin-corrects-the-BDNF-transport-defect-in-1756-6606-2-33-S2.ogv (Ogg Theora video file, length 4.8 s, 443 × 200 pixels, 1.66 Mbps, file size: 980 KB)
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Summary[edit]
| Description |
English: FK506 treatment increases transport of BDNF-containing vesicles in cortical neurons from
HdhQ111/Q111 mice. Representative movies showing the effect of FK506 treatment on the dynamics of BDNF-mCherry vesicles in neurites from cortical primary neurons from knock-in HdhQ111/Q111 mice. The upper movies shows DMSO treated neurons and the lower movies neurons treated with 1 µM FK506 during 30 min. For each movies, 6 randomly chosen vesicles were tracked and visualized as dots using ImageJ software. Videomicroscopy experiments were done as in Methods except that images were collected during 2 minutes at a frequency of 1 image/s with an acquisition time of 300 ms. Scale bar corresponds to 5 µm. |
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| Date | |||
| Source | Pineda J, Pardo R, Zala D, Yu H, Humbert S, Saudou F (2009). "Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's disease". Molecular Brain. DOI:10.1186/1756-6606-2-33. PMID 19860865. PMC: 2776580. | ||
| Author | Pineda J, Pardo R, Zala D, Yu H, Humbert S, Saudou F | ||
| Permission (Reusing this file) |
  This file is licensed under the Creative Commons Attribution 2.0 Generic license.
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 00:10, 20 November 2012 | 4.8 s, 443 × 200 (980 KB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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