File:Model for Nodal signalling in the left-lateral plate mesoderm and activation Pitx2 in the heart morphogenesis in normal human embryos.png
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| Description | Figure 5. Model for Nodal signalling in the left-lateral plate mesoderm and activation Pitx2 in the heart morphogenesis in normal embryos. In the initial event, that translates the motion of primitive nodal cilia (Hensen) toward the left side of the chicken embryo, which regulates the expression of Foxh1 and Pitx2c through the receptor of the activin signaling pathway. Foxh1 determines the rightward direction of the heart loop and the ventricular topology. Pitx2c expression determines the atrial identity. (A) Real embryo. (B) Representation of the possible flow of nodal from the primitive node and the interacting genes. (The PS is exemplified in the central dotted line). Based on Chen CM, Norris D, Bhattacharya S. Transcriptional control of left-right patterning in cardiac development [57]. |
| Date | |
| Source | https://doi.org/10.3390/life13010165 Human Heart Morphogenesis: A New Vision Based on In Vivo Labeling and Cell Tracking. Life 2023, 13, 165. |
| Author | Villavicencio-Guzmán, L.; Sánchez-Gómez, C.; Jaime-Cruz, R.; Ramírez-Fuentes, T.C.; Patiño-Morales, C.C.; Salazar-García, M. |
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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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| current | 20:55, 4 May 2024 | | 3,764 × 1,411 (1.17 MB) | Rasbak (talk | contribs) | {{Information |description=Figure 5. Model for Nodal signalling in the left-lateral plate mesoderm and activation Pitx2 in the heart morphogenesis in normal embryos. In the initial event, that translates the motion of primitive nodal cilia (Hensen) toward the left side of the chicken embryo, which regulates the expression of Foxh1 and Pitx2c through the receptor of the activin signaling pathway. Foxh1 determines the rightward direction of the heart loop and the ventricular topology. Pitx2c ex... |
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