File:Chromophobe renal cell carcinoma, eosinophilic variant - high mag.jpg

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English: High magnification micrograph of chromophobe renal cell carcinoma, oncocytic variant. H&E stain.

The features of chromophobe renal cell carcinoma (ChRCC) are:

  • Pale staining cytoplasm.
  • Periphery of cells distinct.
  • Perinuclear clearing.

The oncocytic variant of ChRCC, seen above, has eosinophilic cytoplasm. The term (ChRCC oncocytic variant), etymologically, may seem self-contradictory, to readers familiar with the fact that oncocytes have eosinophilic cytoplasm; chromophobe means colour-fearing, i.e. something that does not readily take-up dyes.

The main differential diagnosis is renal oncocytoma, which like the oncocytic ChRCC has oncocytic cytoplasm, but lack perinuclear clear and has bland nuclei.
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Author Nephron

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current04:04, 27 August 2009Thumbnail for version as of 04:04, 27 August 20091,920 × 2,616 (1.99 MB)Nephron (talk | contribs){{Information |Description={{en|1=High magnification micrograph of ''''' chromophobe renal cell carcinoma, oncocytic variant'''''. H&E stain. The features of chromophobe renal cell carcinoma (Ch

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