File:Probiotic-associated therapeutic curli hybrids (PATCH).pdf
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DescriptionProbiotic-associated therapeutic curli hybrids (PATCH).pdf |
English: a Schematic overview of engineered curli production. Genetically engineered E. coli Nissle 1917 (EcN) with csg (curli) operon deletion (PBP8 strain) containing plasmids encoding a synthetic curli operon capable of producing chimeric CsgA proteins (yellow chevrons with appended bright green domains), which are secreted and self-assembled extracellularly into therapeutic curli hybrid fibers. b CsgA (yellow), the main proteinaceous component of the E. coli biofilm matrix, was genetically fused to a therapeutic domain—in this case, TFF3 (PDB ID: 19ET, bright green), which is a cytokine secreted by mucus-producing cells. The flexible linker (black) includes a 6xHis tag for detection purposes. c Engineered bacteria are produced in bulk before delivery to the subject via oral or rectal routes. A site of colonic inflammation is highlighted in red. d Interaction of PATCH and the colonic mucosa. Inflammatory lesions in IBD result in loss of colonic crypt structure, damage to epithelial tissue, and compromised barrier integrity (left panel, (−) PATCH). The resulting invasion of luminal contents and recruitment of immune cells to the site exacerbates the local inflammation. The application of PATCH (right panel, (+) PATCH) reinforces barrier function, promotes epithelial restitution, and dampens inflammatory signaling to ameliorate IBD activity.[1] |
Date | |
Source | https://doi.org/10.1038/s41467-019-13336-6 |
Author | Pichet Praveschotinunt, Anna M. Duraj-Thatte, Ilia Gelfat, Franziska Bahl, David B. Chou & Neel S. Joshi |
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Short title | Probiotic-associated therapeutic curli hybrids (PATCH).pdf |
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Software used | Serif Affinity Designer (Mar 31 2020) |
Conversion program | PDFlib+PDI 9.1.2p1-i (OS X/macOS) |
Encrypted | no |
Page size | 486 x 352.8 pts |
Version of PDF format | 1.7 |
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