File:GWAS loci influencing human facial and scalp hair phenotypes - cropped.png
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[edit]DescriptionGWAS loci influencing human facial and scalp hair phenotypes - cropped.png |
English: Genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features. At the top are shown drawings illustrating the seven hair features examined in the CANDELA study sample. Thick lines connect these features with the candidate genes identified in regions with SNPs reaching genome-wide significant association (Table 1). Composite panels in this figure was made using Photoshop. |
Date | Published 2016-03-01 |
Source | Kaustubh Adhikari et al. 'A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features.' Nature Communications 7, Article number: 10815 doi:10.1038/ncomms10815 http://www.nature.com/ncomms/2016/160301/ncomms10815/full/ncomms10815.html |
Author | Kaustubh Adhikari, Tania Fontanil, Santiago Cal, Javier Mendoza-Revilla, Macarena Fuentes-Guajardo, Juan-Camilo Chacón-Duque, Farah Al-Saadi, Jeanette A. Johansson, Mirsha Quinto-Sanchez, Victor Acuña-Alonzo, Claudia Jaramillo, William Arias, Rodrigo Barquera Lozano, Gastón Macín Pérez, Jorge Gómez-Valdés, Hugo Villamil-Ramírez, Tábita Hunemeier, Virginia Ramallo, Caio C. Silva de Cerqueira, Malena Hurtado, Valeria Villegas, Vanessa Granja, Carla Gallo, Giovanni Poletti, Lavinia Schuler-Faccini, Francisco M. Salzano, Maria-Cátira Bortolini, Samuel Canizales-Quinteros, Francisco Rothhammer, Gabriel Bedoya, Rolando Gonzalez-José, Denis Headon, Carlos López-Otín, Desmond J. Tobin, David Balding and Andrés Ruiz-Linares. |
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Regions with intragenic index SNPs are shown in bold (the gene name is underlined if this index SNP is coding). SNPs in regions reaching only genome-wide suggestive association, P value <10−5, are listed in Supplementary Table 6
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Trait | Region | SNP | Closest gene | P value | Alleles ancestral>derived |
---|---|---|---|---|---|
Hair shape | 1q21 | rs11803731 | TCHH | 3 × 10−12 | A>T |
Hair shape | 2q12 | rs3827760 | EDAR | 3 × 10−119 | A>G |
Hair shape | 10p14 | rs17143387 | GATA3 | 4 × 10−8 | T>G |
Hair shape | 16p11 | rs11150606 | PRSS53 | 7 × 10−9 | T>C |
Beard thickness | 2q12 | rs365060 | EDAR | 1 × 10−15 | G>C |
Beard thickness | 4q12 | rs4864809 | LNX1 | 1 × 10−8 | A>G |
Beard thickness | 6q21 | rs6901317 | PREP | 4 × 10−8 | G>T |
Beard thickness | 7q31 | rs117717824 | FOXP2 | 1 × 10−8 | G>T |
Eyebrow thickness | 3q22 | rs112458845 | FOXL2 | 4 × 10−10 | G>A |
Monobrow | 2q36 | rs2218065 | PAX3 | 5 × 10−8 | A>G |
Hair greying | 6p25 | rs12203592 | IRF4 | 3 × 10−13 | C>T |
Hair colour | 5p13 | rs183671 | SLC45A2 | 2 × 10−59 | T>G |
Hair colour | 6p25 | rs12203592 | IRF4 | 1 × 10−13 | C>T |
Hair colour | 11q14 | rs598952 | TYR | 2 × 10−8 | T>A |
Hair colour | 15q13 | rs12913832 | HERC2/OCA2 | 5 × 10−104 | A>G |
Hair colour | 15q21 | rs1426654 | SLC24A5 | 1 × 10−18 | G>A |
Balding | 10q22 | rs2814331 | GRID1 | 4 × 10−9 | C>T |
Balding | Xq12 | rs4258142 | AR/EDA2R | 2 × 10−8 | C>T |
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