File:Modeling and statistical analysis of Medaka bioassay data (IA modelingstatisti00gave).pdf

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Modeling and statistical analysis of Medaka bioassay data   (Wikidata search (Cirrus search) Wikidata query (SPARQL)  Create new Wikidata item based on this file)
Author
Gaver, Donald Paul.;Jacobs, Patricia A.
image of artwork listed in title parameter on this page
Title
Modeling and statistical analysis of Medaka bioassay data
Publisher
Monterey, California : Naval Postgraduate School
Description
Cover title
"NPS-OR-92-012."
"May 1992."
AD A252 844
Includes bibliographical references (p. 18-19)
A histopathologic examination of tissues from Oryzias laptipes (Japanese medaka fish) was performed to evaluate the carcinogenic potential of tricholoroethylene (TCE) in groundwater. The data were reported by Experimental Pathology Laboratories, Inc., in a report dated Jan. 19, 1990, submitted to the Army Biomedical Research and Development Laboratory, Ft. Detrick, MD. This paper provides a brief statistical analysis of some aspects of those data. The analysis does not reveal a strong positive relationship between TCE concentration over the range considered and probability (risk or hazard) of incurring at least one end point manifestation (here cystic degeneration or liver neoplasm) in a fish. Uncertainties in the point estimates are assessed by bootstrapping. Both non-parametric (weak statistical assumptions) and parametric (stronger statistical assumptions) analyses give similar inconclusive dose- response indications. A brief discussion is included of a biologically-based mathematical model that is likely to form an appropriate basis for more sophisticated data analysis. One contribution of this paper is to discuss and illustrate techniques for quantitative analysis of other similar data. The methods can also be used to assist in choosing an experimental design. Binomial Distribution; Censored data; Generalized linear model; Bootstrap
aq/aq cc:9116 07/08/97

Subjects: FISHES.; PATHOLOGY.; GROUND WATER.; TRICHLOROETHYLENE.; TOXICITY.
Language en_US
Publication date May 1992
publication_date QS:P577,+1992-05-00T00:00:00Z/10
Current location
IA Collections: navalpostgraduateschoollibrary; fedlink; americana
Accession number
modelingstatisti00gave
Authority file  OCLC: 1049684602
Source
Internet Archive identifier: modelingstatisti00gave
https://archive.org/download/modelingstatisti00gave/modelingstatisti00gave.pdf

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Public domain
This work is in the public domain in the United States because it is a work prepared by an officer or employee of the United States Government as part of that person’s official duties under the terms of Title 17, Chapter 1, Section 105 of the US Code. Note: This only applies to original works of the Federal Government and not to the work of any individual U.S. state, territory, commonwealth, county, municipality, or any other subdivision. This template also does not apply to postage stamp designs published by the United States Postal Service since 1978. (See § 313.6(C)(1) of Compendium of U.S. Copyright Office Practices). It also does not apply to certain US coins; see The US Mint Terms of Use.
This file has been identified as being free of known restrictions under copyright law, including all related and neighboring rights.

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current16:29, 9 July 2020Thumbnail for version as of 16:29, 9 July 20201,172 × 1,614, 40 pages (1.69 MB)Fæ (talk | contribs)FEDLINK - United States Federal Collection modelingstatisti00gave (User talk:Fæ/IA books#Fork8) (batch 1990-1992 #5826)

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