Chinese subtitles for clip: File:About Lulu and Nana- Twin Girls Born Healthy After Gene Surgery As Single-Cell Embryos.webm
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1 00:00:00,000 --> 00:00:05,188 有两个可爱的小女孩几周前诞生了。 2 00:00:05,205 --> 00:00:11,064 她们的名字叫露露和娜娜 3 00:00:11,553 --> 00:00:16,677 现在他们和妈妈葛女士 爸爸马先生起平安出院回家。 4 00:00:17,864 --> 00:00:22,850 葛女通过常规试管婴儿技术开始怀孕 但有一点不同的是 5 00:00:23,948 --> 00:00:28,327 在我的将丈夫的精子注入卵子后 6 00:00:28,405 --> 00:00:33,854 还注射了一点点蛋白质 和指引信号去做基因手术。 7 00:00:34,965 --> 00:00:40,356 在露露和娜娜还是单细胞时候 8 00:00:40,374 --> 00:00:46,974 去关闭艾滋病毒感染的大门 筒单说就是能够天然抵抗艾滋病。 9 00:00:47,849 --> 00:00:53,751 随后我们进行全基因组测序 10 00:00:53,796 --> 00:00:58,520 去检查了基因手术的情况 11 00:00:58,710 --> 00:01:05,522 在确保手术按预期安全地进行后 在葛女士怀孕期间 12 00:01:06,465 --> 00:01:09,245 我们将还是胚胎的露露娜娜 移植进葛女士子富。 13 00:01:09,294 --> 00:01:13,379 我们__过B超和血液检查密 切监测胎儿发育情况 14 00:01:13,879 --> 00:01:19,184 …. 交檢香密出生后, 15 00:01:19,536 --> 00:01:23,272 我们再次深入对露露娜娜的全基因组 进行测序再次证实基因手术的安全性: 16 00:01:23,964 --> 00:01:28,928 除了防止HIV感染的基因外 没有改变其他基因。 17 00:01:29,529 --> 00:01:34,542 [Not yet transcribed] 18 00:01:36,252 --> 00:01:40,131 When Mark saw his daughters for the first time, 19 00:01:40,154 --> 00:01:45,047 he said that he never thought he could be a father. 20 00:01:45,392 --> 00:01:51,850 Now he's found a reason to live, a reason to work, a purpose. 21 00:01:52,097 --> 00:01:55,276 You see, Mark has HIV. 22 00:01:55,322 --> 00:01:59,833 Discrimination in many developing countries makes the virus worse. 23 00:02:00,583 --> 00:02:04,469 Employers fire people like Mark, 24 00:02:04,491 --> 00:02:09,802 doctors deny medical care and even forcibly sterilize women. 25 00:02:10,078 --> 00:02:15,500 Mark and Grace couldn't bear to bring a child into that world of fear. 26 00:02:16,092 --> 00:02:20,667 Mark's words taught me something that I couldn't fully appreciate. 27 00:02:21,189 --> 00:02:24,947 A gene surgery that could save a child 28 00:02:24,978 --> 00:02:29,184 from a lethal genetic disease like cystic fibrosis 29 00:02:29,241 --> 00:02:32,774 or from a life-threatening infection like HIV 30 00:02:32,799 --> 00:02:39,035 doesn't just give that little boy or girl an equal chance at a healthy life: 31 00:02:39,463 --> 00:02:41,434 we heal a whole family. 32 00:02:41,732 --> 00:02:44,517 As a father of two girls, 33 00:02:44,550 --> 00:02:49,301 I can't think of a gift more beautiful and wholesome to society 34 00:02:49,330 --> 00:02:53,767 than giving another couple a chance to start a loving family. 35 00:02:54,624 --> 00:03:00,294 The media hyped panic about Louise Brown's birth as the first IVF baby. 36 00:03:00,811 --> 00:03:06,628 But for forty years, regulation and morals have developed together for IVF, 37 00:03:06,706 --> 00:03:09,547 ensuring only therapeutic applications 38 00:03:09,578 --> 00:03:12,983 to help more than 8 million children come into this world. 39 00:03:13,473 --> 00:03:17,353 Gene surgery is another IVF advancement 40 00:03:18,005 --> 00:03:22,314 and is only meant to help a small number of families. 41 00:03:23,295 --> 00:03:24,945 For a few children, 42 00:03:24,990 --> 00:03:31,042 early gene surgery may be the only viable way to heal an inheritable disease 43 00:03:31,071 --> 00:03:33,591 and prevent a lifetime of suffering. 44 00:03:33,992 --> 00:03:37,514 We hope you have mercy for them. 45 00:03:37,992 --> 00:03:40,888 Their parents don't want a designer baby, 46 00:03:40,918 --> 00:03:47,455 just a child who won't suffer from a disease that medicine can now prevent. 47 00:03:48,212 --> 00:03:53,032 Gene surgery is and should remain a technology for healing. 48 00:03:53,278 --> 00:03:57,486 Enhancing IQ or selecting hair or eye color 49 00:03:57,502 --> 00:04:00,592 is not what a loving parent does. 50 00:04:00,806 --> 00:04:02,478 That should be banned. 51 00:04:02,950 --> 00:04:06,610 I understand my work will be controversial, 52 00:04:06,659 --> 00:04:10,859 but I believe families need this technology 53 00:04:10,931 --> 00:04:15,434 and I'm willing to take the criticism for them. 54 00:04:16,218 --> 00:04:19,804 So you can know more about our moral values and work, 55 00:04:19,861 --> 00:04:23,566 we've posted a few more simple videos. 56 00:04:24,437 --> 00:04:28,269 You can also visit our lab's website via the link below. 57 00:04:28,381 --> 00:04:32,687 If you wish to write Lulu and Nana or me, 58 00:04:32,728 --> 00:04:35,254 use the emails on your screen.